Propofol-related infusion syndrome heralding a mitochondrial disease: Case report

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Propofol infusion syndrome.

The clinical features of propofol infusion syndrome (PRIS) are acute refractory bradycardia leading to asystole, in the presence of one or more of the following: metabolic acidosis (base deficit > 10 mmol.l(-1)), rhabdomyolysis, hyperlipidaemia, and enlarged or fatty liver. There is an association between PRIS and propofol infusions at doses higher than 4 mg.kg(-1).h(-1) for greater than 48 h d...

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Green Urine Discoloration due to Propofol Infusion: A Case Report

We present a 19-year-old man who excreted green urine after propofol infusion. The patient was admitted to our hospital for injuries sustained in a traffic accident and underwent surgery. After starting continuous infusion of propofol for postoperative sedation, his urine became dark green. Serum total bilirubin and urine bilirubin were both elevated. We believe that the green discoloration of ...

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Propofol Infusion Syndrome in Refractory Status Epilepticus: A Case Report and Topical Review

Propofol infusion syndrome (PRIS) is a fatal complication when doses of propofol administration exceed 4 mg/kg/h for more than 48 hours. Propofol overdosage is not uncommon in patients with refractory status epilepticus (RSE). We describe a case of refractory status epilepticus complicated by propofol infusion syndrome and collect from 5 databases all reports of refractory status epilepticus ca...

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Propofol infusion syndrome resuscitation with extracorporeal life support: a case report and review of the literature

We report a case of propofol infusion syndrome (PRIS) in a young female treated for status epilepticus. In this case, PRIS rapidly evolved to full cardiovascular collapse despite aggressive supportive care in the intensive care unit, as well as prompt discontinuation of the offending agent. She progressed to refractory cardiac arrest requiring emergent initiation of venoarterial extracorporeal ...

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Suggested beginning of propofol infusion syndrome in an adult patient without lactacidosis: a case report.

EDITOR: Propofol infusion syndrome (PRIS) is a rare and often fatal disease associated with propofol sedation at doses of more than 5 mg kg h for more than 48 h. PRIS is characterized by lipaemic plasma, fatty liver enlargement, metabolic acidosis, rhabdomyolysis or myoglobinuria, cardiac arrhythmia and acute bradycardia progressing to asystole. The syndrome usually occurs in patients with cent...

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ژورنال

عنوان ژورنال: Neurology

سال: 2014

ISSN: 0028-3878,1526-632X

DOI: 10.1212/01.wnl.0000443933.18269.20